Satisfaction with life and psychological distress during the COVID-19 pandemic: An Egyptian online cross-sectional study.

BACKGROUND: Coronavirus disease 2019 (COVID-19) is a novel sickness that emerged worldwide as an unprecedented crisis and led to major effects on the daily life of the general public as well as negative impacts on their mental well-being. AIM: This study aimed to assess satisfaction with life and psychological distress during the COVID-19 pandemic in Egypt. SETTING: An online study was conducted in Egypt. METHODS: A cross-sectional online survey was fulfilled by 1056 Egyptian adults from 06 to 13 June 2020. Psychological distress and satisfaction with life were measured by Arabic validated versions of the Kessler Psychological Distress Scale (K10) and the Satisfaction with Life Scale (SWLS). RESULTS: About half of the surveyed respondents (51%) were satisfied with their life, whilst 57.4% experienced severe psychological distress. The independent predictors of satisfaction with life are being married, satisfactory income, low distress, moderate distress and high distress (adjusted odds ratio [AOR] = 1.2, 3.0, 2.5, 6.9, 5.2 and 2.1, respectively). Being a female, having secondary education, secondary education, unsatisfactory income and presence of mental illness are the independent predictors of mental distress (AOR = 2.3, 3.9, 1.9, 1.9, 1.6 and 4.0, respectively). CONCLUSION: The study provides evidence about the high prevalence of psychological distress during the peak period of Egypt's COVID-19 pandemic. The study results highlight the enhancement of development interventions to promote psychological well-being and feeling of satisfaction with life during the pandemic.

Effect of a combination of nitazoxanide, ribavirin, and ivermectin plus zinc supplement (MANS.NRIZ study) on the clearance of mild COVID-19.

This trial compared the rate and time of viral clearance in subjects receiving a combination of nitazoxanide, ribavirin, and ivermectin plus Zinc versus those receiving supportive treatment. This non-randomized controlled trial included 62 patients on the triple combination treatment versus 51 age- and sex-matched patients on routine supportive treatment. all of them confirmed cases by positive reverse-transcription polymerase chain reaction of a nasopharyngeal swab. Trial results showed that the clearance rates were 0% and 58.1% on the 7th day and 13.7% and 73.1% on the 15th day in the supportive treatment and combined antiviral groups, respectively. The cumulative clearance rates on the 15th day are 13.7% and 88.7% in the supportive treatment and combined antiviral groups, respectively. This trial concluded by stating that the combined use of nitazoxanide, ribavirin, and ivermectin plus zinc supplement effectively cleared the SARS-COV2 from the nasopharynx in a shorter time than symptomatic therapy.

COVID-19 caseness: An epidemiologic perspective.

The concept of caseness in the COVID-19 virus is important for early case finding and reporting. These are essential steps for prevention and control. This review defines and differentiates between types of cases and specifies the elements of each case definition in general with their application to COVID-19, where appropriate. These terms and their application are useful for the surveillance team, epidemiologists, clinicians, policy makers as well as the public in general.

Psychological distress among Egyptian physicians during COVID-19 pandemic.

OBJECTIVE: The current study's main objective was to measure the prevalence of psychological distress and its associated factors among Egyptian physicians during the COVID-19 pandemic. Perceived stressors and coping strategies were also explored. METHODS: A cross-sectional study on 714 physicians was carried out using an online administered questionnaire. The questionnaire included sociodemographic and occupational data, data related to the current pandemic, Kessler psychological distress scale, and the brief resilient coping scale. Multivariable logistic regression analysis was performed to identify significant predictors. RESULTS: About 50% of physicians had severe psychological distress. Among studied physicians, the significant predictors were being female, having a pre-existing illness, having an elderly family member, and being in close contact with a case (AOR 1.6, 1.6, 1.4 and 1.7, respectively). Meanwhile, significant occupational predictors were less experienced and frontline physicians (AOR 2.0 and 1.8, respectively). The most distressful concern was fear for families and personal health and safety, while religious coping was the most effective coping strategy. CONCLUSION: During the current pandemic, Egyptian physicians have a high prevalence of psychological distress. Frontline, low-experienced, female, previously ill physicians are more likely to have severe psychological distress. Therefore, psychological preparedness and psychological support services should be implemented and made easily accessible during pandemics.